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An amino acid sequence coded by the Exon 2 of the BoLA DRB3 gene associated with a BoLA class I genetic marker of resistance to dermatophilosis in Braham zebu cattle of Martinique (FWI)

Maillard J.C., Martinez D., Bensaïd A.. 1996. Annals of the New York Academy of Sciences, 791 (791) : p. 185-197. Symposium on Vector-Borne Pathogens: Challenges for the 21st Century and International Trade and Animal Diseases. 3, 1995-05-08/1995-05-12, San José (Costa Rica).

One hundred and twenty-seven Brahman cattle from several locations in Martinique (FWI), reared under different environmental conditions, were followed over three years and checked for clinical signs of derrnatophilosis. To confirm that these animals had been in contact with the pathogen Dermatophilus congolensis, their sera were tested by ELISA. On the basis of this epidemiological study, 12 animals were classified as resistant (seropositive without clinical signs), belonging to herds in which the prevalence of the disease ranged from 25 to nearly 98%. Eighteen animals classified as highly susceptible displayed severe characteristic skin lesions. These 30 selected animals were typed for class I antigens of the major histocompatibilit y complex (MHC). MHC class II genes were analyzed using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) techniques on the exon 2 of the bovine leucocyte antigen (BoLA) DRB3 gene

Mots-clés : marqueur génétique; résistance aux maladies; zébu; dermatophilus congolensis; martinique

Thématique : Organismes nuisibles des animaux

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