Publications des agents du Cirad

Cirad

Inhibitory effect of Cowdria ruminantium on the expression of MHC Class I and Class II molecules on bovine endothelial cells

Vachiery N., Trap I., Totté P., Martinez D., Bensaïd A.. 1998. Annals of the New York Academy of Sciences, 849 : p. 181-187. Biennial Conference of the Society for Tropical Veterinary Medecine. 4, 1997-05-05/1997-05-09, Montpellier (France).

Bovine endothelial cells constitutively express MHC class I molecules, whereas MHC class II molecules can be induced by interferon gamma (IFNy) treatment. Endothelial cells may play a role as antigen presenting cells (APC), but their role in the immune response against Cowdria ruminantium is unknown. We have studied the effect of C.ruminantium infection on the expression of MHC class I and class II molecules on the surface of bovine endothelial cells. Bovine brain endothelial cells (BBEC) from the microvasculature and bovine umbilical endothelial cells (BUEC) from the macrovasculature were cultured in vitro, infected with different concentration of Cowdria, and treated or not with IFNy. We observed that Cowdria induced a reduction of MHC molecules expression on the surface of BUEC and BBEC. This inhibitory effect of Cowdria on MHC molecules could affect the capacity of endothelial cells to act as efficient antigen-presenting cells. (Résumé d'auteur)

Mots-clés : antigène; rickettsia; cellule; réponse immunitaire; interféron; ehrlichia ruminantium; cellule endothéliale bovine

Thématique : Organismes nuisibles des animaux

Article de revue

Agents Cirad, auteurs de cette publication :