Although the primary effect of animal feed is to contribute to animal health, defects in its composition can at times negatively influence the sanitary quality of animal products consumed by humans. A range of factors make the management of these problems more difficult in developing countries: climate more favorable to microbial and fungal contamination, less structured supply chains (with fewer in-built incentives for quality assurance), limited resources to conduct monitoring and testing. This article reviews some of the major potential hazards in feed – aflatoxins, feed additives, and feed-borne microbial contamination – and explores potential solutions in the context of developing country supply chains, such as the use of non-toxic and inexpensive additives. There is a pressing need for objective and original research in this area.