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Heterologous production of Albicidin : a promising approach to overproducing and characterizing this potent inhibitor of DNA Gyrase

Vivien E., Pitorre D., Cociancich S., Pieretti I., Gabriel D.W., Rott P., Royer M.. 2007. Antimicrobial Agents and Chemotherapy, 51 (4) : p. 1549-1552.

DOI: 10.1128/AAC.01450-06

The phytotoxin and polyketide antibiotic albicidin produced by Xanthomonas albilineans is a highly potent DNA gyrase inhibitor. Low yields of albicidin production have slowed studies of its chemical structure. Heterologous expression of albicidin biosynthetic genes in X. axonopodis pv. vesicatoria resulted in a sixfold increase in albicidin production, offering promising strategies for engineering overproduction.

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