Background. Tephritid flies are major economic pests for crop production worldwide. On La Réunion, three species (Bactrocera cucurbitae, Dacus ciliatus and D. demmerezi) cause high yield losses for cucurbits growers. Up to now, control exclusively relied on agrochemistry. Since 2009, CIRAD initiated a three years cooperative program of agro-ecological management of vegetables flies (GAMOUR). This areawide research and extension program gathers twelve local or national organisms specialised in agricultural support. It aims to bring a sustainable methodology to suppress pest populations. i.e. to develop and implement technical innovations that are both economically viable and environmentally friendly. Methods. We designed a technical package based on the existing foreign experiences, and particularly the experience of researchers in Hawaii, with monitoring, sanitation, bait sprays on border crops, male annihilation by mass trapping, conservative biocontrol and agroecological engineering. In pilot areas, vegetables growers were then requested to conduct an initial survey of agricultural practices. They were afterwards proposed the package in September 2009. Since that, the ecological, social and economical impacts were assessed by a weekly monitoring of flies population and a survey of agricultural practices. Results. GAMOUR is currently running in three pilot areas on La Réunion (Salazie, Entre-Deux and Petite Ile), with 27 farmers cumulating about 50 ha of vegetable crops (25% of cucurbits). For most of them, the usual method of protection against flies was purely chemical, with a mean of 1 to 3 insecticide cover sprays per week. Moreover, as the technical package is compatible with organic farming as well, four organic farms were included as pilot sites in Bras-Panon, Etang-Salé, Colimaçons, and Boucan-Canot. After one year, in all three pilot areas, curative treatments based on classical pesticides have been almost totally stopped. Meanwhile, the growers decl