The Caribbean region is composed of many scattered and diverse islands that are highly heterogeneous in terms of size, sociodevelopment level, political status, culture, environment, animal production systems, etc. The regular occurrence of natural disasters and sudden environmental and anthropologic changes increase disparity between islands and make the Caribbean particularly sensitive to the emergence of diseases. Globalization, trade, and animal and human movements increase the risk of disease circulation. Since the failure of veterinary services and surveillance activities in one country may threaten the whole region, a regional approach to building skills in surveillance and control of animal diseases in the Caribbean is essential. The Caribbean Animal Health Network, CaribVETi, is a regional collaborative network involving veterinary services, laboratories, and research institutes in 32 countries/territories as well as numerous regional/international organizations. The objective of this network is to improve the animal health situation in the Caribbean. To reach that goal, CaribVET promotes the harmonization and reinforcement of animal disease surveillance and control activities in the Caribbean by organizing training sessions for professionals at different levels (field workers, veterinary services, laboratory technicians) to improve their technical and scientific skills. The capacity building implemented in the region focuses on disease knowledge and epidemiology, surveillance and control protocols, information and data flows, and diagnostic tests. To build an efficient and sustainable network of skills in the Caribbean, evaluations of activities related to disease surveillance and control, as well as personnel are performed at both national and regional levels.