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Dilobenol A-G, Diprenylated Dihydroflavonols from the Leaves of Dilobeia thouarsii

Razafintsalama V., Girardot M., Randrianarivo R., Rakoto D., Sarter S., Petit T., Ralambonirina S., Deville A., Grellier P., Jeannoda V., Mambu L.. 2013. European Journal of Organic Chemistry, 2013 (10) : p. 1929-1936.

DOI: 10.1002/ejoc.201201421

The study of the EtOAc extract of the leaves of Dilobeia thouarsii led to the isolation and identification of seven new diprenylated dihydroxyflavonols named dilobenol A-G (1-7). Their structures were elucidated by spectroscopic analysis including UV, IR, 1D and 2D NMR and MS as well as by chemical hydrolysis. The isolated compounds were assessed for their antibacterial, antiplasmodial and cytotoxic activities. They exhibited moderate growth inhibitory activities against Staphylococcus aureus, Vibrio spp., Bacillus spp, and Plasmodium falciparum without significant toxicity against mammalian cell line L-6.

Mots-clés : proteaceae; plante médicinale; flavonoïde; extrait d'origine végétale; feuille; antiprotozoaire; antimicrobien; propriété antimicrobienne; toxicité; vibrio; plasmodium falciparum; bacillus; staphylococcus aureus; structure chimique; spectrométrie; madagascar; dilobeia thouarsii

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