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Characterization of anamnestic T-cell responses induced by conventional vaccines against contagious bovine pleuropneumonia

Totté P., YaYa A., Sery A., Wesonga H., Wade A., Naessens J., Niang M., Thiaucourt F.. 2013. PloS One, 8 (2) : 6 p..

A better understanding of how T1 vaccination confers immunity would facilitate the rational design of improved vaccines against contagious bovine pleuropneumonia (CBPP). We show here that mycoplasmas-induced recall proliferation and IFN-c responses are detected in cattle that received multiple shots of T1 vaccines. These anamnestic responses were under the strict control of CD4+ T lymphocytes. Moreover, CD62L expression indicated that both CD4+ effector memory (Tem) and central memory (Tcm) T lymphocytes are elicited in these animals. Comparative analysis with data from cattle that completely recovered from CBPP infection revealed similar anamnestic T-cell responses albeit at a lower magnitude for T1- vaccinated animals, particularly in the Tcm compartment. In conclusion, we discuss how our current understanding of T-cell responses will contribute to ongoing efforts for the improvement of future CBPP vaccines. (Résumé d'auteur)

Mots-clés : vaccination; réponse immunitaire; lymphocyte; immunologie; vaccin; bovin; mycoplasma mycoides; péripneumonie contagieuse bovine; mali; kenya; cameroun; production de vaccin

Thématique : Maladies des animaux; Physiologie et biochimie animales

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