The abscisic acid (ABA) is a vital phytohormone synthesized in roots and leaves, acting as central regulator involved in plant responses against abiotic stress, such as drought. It mediates stress-responsive gene expression by controlling stomatal closure, root growth modulation and seed dormancy, for example. Water deficit affects coffee plant development and production and consequently the biochemical composition of beans. It is also well known that genetic variability exists in the Coffea species for drought tolerance. Recently, novel intracellular ABA receptors (PYL/RCARs) involved in ABA sensing and signaling were identified. A mechanism of ABA transduction was proposed, involving PYR/PYL/RCARs ABA receptors interacting with PP2Cs phosphatases and SnRK2 protein kinases. The goal of this study was to identify and characterize orthologous genes of PYR/PYL/RCAR family in C. canephora. For this purpose, protein sequences from Arabidopsis, citrus, rice, grape and tomato species were chosen as query to search orthologous genes in coffee genome. This approach allowed the identification and characterization of 9 candidate genes for PYR/PYL/RCAR family in C. canephora genome. The protein domains identified in the predict coffee sequences enabled to characterize these genes as family's members of receptors of ABA response pathway. Phylogenetic analysis allowed classifying coffee polypeptides sequences in three subfamilies expected. These genes were functionally annotated in the Coffee Genome Hub (http://coffee-genome.org/). In silico analyses also revealed differential expression profiles of coffee PYR/PYL/RCAR genes in tissues such as leaves, seeds, and floral organs, although, the highest expression profiles were identified in roots. Regarding drought stress, in silico analyses from RNAseq data obtained from roots of tolerant (Cc14, Cc73, Cc120) and susceptible (Cc22) clones of C. canephora grown with (I) or without (NI) irrigation also confirmed differential expressio