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Tolerance to trypanosomatids: A threat, or a key for disease elimination?

Berthier D., Brenière S.F., Bras-Gonçalves R., Lemesre J.L., Jamonneau V., Solano P., Lejon V., Thevenon S., Bucheton B.. 2016. Trends in Parasitology, 32 (2) : p. 157-168.

So far, research on trypanosomatid infections has been driven by 'disease by disease' approaches, leading to different concepts and control strategies. It is, however, increasingly clear that they share common features such as the ability to generate long-lasting asymptomatic infections in their mammalian hosts. Trypanotolerance, long integrated in animal African trypanosomiasis control, historically refers to the ability of cattle breeds to limit Trypanosoma infection and pathology, but has only recently been recognized in humans. Whilst trypanotolerance is absent from the vocabulary on leishmaniasis and Chagas disease, asymptomatic infections also occur. We review the concept of trypanotolerance across the trypanosomatids and discuss the importance of asymptomatic carriage in the current context of elimination. (Résumé d'auteur)

Mots-clés : trypanosoma brucei; genre humain; mammifère; bovin; contrôle de maladies; Éradication des maladies; résistance génétique; résistance aux maladies; tolérance; leishmania; trypanosoma; trypanosomose africaine; trypanosomose; monde; trypanosoma brucei gambiense; trypanosoma brucei rhodesiense

Thématique : Maladies des animaux; Autres thèmes; Organismes nuisibles des animaux

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