The immunity profile against H5N1 HPAI in the commercial poultry value chain network in Egypt was modelled using different vaccination scenarios. The model estimated the vaccination coverage, the protective sero-conversion level and the duration of immunity for each node of the network and vaccination scenario. Partial budget analysis was used to compare the cost-benefit of the different vaccination scenarios. The model predicted that targeting DOC AI vaccination in industrial and large size hatcheries would increase immunity levels in the overall poultry population in Egypt and especially in small commercial poultry farms (from <30% to >60%). This strategy was shown to be more efficient than the current strategy using inactivated vaccines. Improving HPAI control in the commercial poultry sector in Egypt would have a positive impact effect to improve disease control.