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Epigenetic regulation of antagonistic receptors confers rice blast resistance with yield balance.

Deng Y.W., Zhai K., Xie Z., Yang D., Zhu X.D., Liu J., Wang X., Qin P., Yang Y., Zhang G., Li Q., Zhang J., Wu S., Milazzo J., Mao B., Wang E., Xie H., Tharreau D., He Z.. 2017. Science, 355 (6328) : p. 962-965.

Crop breeding aims to balance disease resistance with yield, however single resistance (R) genes can lead to resistance breakdown and R gene pyramiding may impact growth fitness. Here we report that the rice Pigm locus contains a cluster of genes encoding nucleotide-binding leucine-rich repeat (NLR) receptors that confer durable resistance to the fungus Magnaporthe oryzae without yield penalty. In the cluster, PigmR confers broad-spectrum resistance, whereas PigmS competitively attenuates PigmR homodimerization to suppress resistance. PigmS expression, and thus PigmR-mediated resistance, are subjected to tight epigenetic regulation. PigmS increases seed production to counteract the yield cost induced by PigmR. Therefore, our study reveals a mechanism balancing high disease resistance and yield through epigenetic regulation of paired antagonistic NLRs, providing a tool to develop elite crop varieties. (Résumé d'auteur)

Mots-clés : amélioration des plantes; génétique; leucine; rendement des cultures; résistance génétique; résistance aux maladies; mécanisme de défense; magnaporthe; oryza sativa; oryza sativa japonica; oryza sativa indica; magnaporthe oryzae; Épigénétique

Thématique : Génétique et amélioration des plantes; Maladies des plantes

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