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Ehrlichia's molecular tricks to manipulate their host cells

Moumène A., Meyer D.. 2016. Microbes and Infection, 18 (3) : p. 172-179.

DOI: 10.1016/j.micinf.2015.11.001

Ehrlichia is a large genus of obligate intracellular Gram-negative bacteria transmitted by ticks that cause several emerging infectious diseases in humans and are pathogenic on rodents, ruminants, and dogs. Ehrlichia spp. invade and replicate either in endothelial cells, white blood cells, or within midgut cells and salivary glands of their vector ticks. In this review, we discuss the insights that functional studies are providing on how this group of bacteria exploits their host by subverting host innate immunity and hijacking cellular processes.

Mots-clés : ehrlichia; biologie moléculaire; relation hôte pathogène; bactériologie; Épidémiologie; transmission des maladies; maladie transmise par vecteur; effecteur moléculaire; animal domestique; animal sauvage; genre humain; ruminant; ovin; rodentia; ehrlichia ruminantium

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