Phenolipids correspond to the covalent grafting of a lipophilic moiety to a phenolic compound in order to modify its hydrophilic/lipophilic balance and adjust its properties. These compounds have already proven to be excellent antioxidants against lipid oxidation in heterogeneous systems such as food emulsions or cosmetic formulations. Herein, we discuss the potential of phenolipids as biological agents in cells or as new antimicrobials.