Huanglongbing (HLB) is a bacterial disease caused by the phloem restricted bacteria Candidatus liberibacter spp. In Guadeloupe, the disease has been present since 2012 and is responsible of the eradication of most of the orchards. In the field, trees in water deficit condition are more sensitive to the disease. Various studies showed that tetraploid (4x) rootstocks confer a better adaptation to drought condition. Also, recent work of CIRAD showed that triploid (3x) Tahiti lime are more tolerant to HLB than the respective diploid (2x) Mexican lime. Thus, we initiated a study to verify whether the use of 4x rootstocks in association with 3x lime can improve tree adaptation to water deficit. 2x and 3x limes grafted onto 2x and 4x rootstocks were evaluated. Physiological and biochemical traits were investigated. Preliminary results suggest that 4x rootstock confer a better tolerance to the scion. Also, better detoxification seems to occur in the triploid scion. This experiment will be coupled to gene expression studies in roots and leaves.