The agricultural sector in Côte d'Ivoire faces the continuous rise of urban and periurban agriculture and the excessive use of synthetic pesticides. This study estimates the effects of combined insect-proof nets with Neem and Carapa oil on the yield and the profitability of tomato cropping systems. An experimental trial was composed of three types of pest management strategies : an untreated control, a treatment with Neem and Carapa oil, and two treatments which combined plants extracts and insects-proof nets. The double difference and cost-benefit analysis methods were used for the economic assessment. Our results revealed a significant difference in average yields between cropping systems. The yield with combined insect-proof nets with Neem and Carapa oil is almost 3 times greater than the control (6.6 t.ha-1 vs 16.1 t.ha-1) in the dry season. There is no significant difference during the rainy season. The Benefit:Cost ratio is 1.90:1 for Neem and Carapa oil only and 2.98:1 for Neem and Carapa oil with insect-proof nets. The cost of the insect-proof cause the difference in the Benefit:Cost ratio. The sensitivity analysis reveals that the tomato cropping systems, remain profitable even when farm-gate prices and production decrease by 20% and 30% respectively, and production costs increase by 30%. Iron frames and insect-proof nets are not yet considered as agricultural investments. A tax policy considering iron frames and insect-proof nets as agriculture investments, would lower the tax rate from 20% to 5%, and therefore improve the Benefit:Cost ratio. A supply chain policy aiming at producing insect-proof net locally, would generate economies of scale and therefore lower the unit price of insect-proof nets. Other policies could consist in in technology support and training. There is a need to perform a sustainability assessment of the Neem and Carapa oil supply chains.