As preliminary results of a research program on animal production in agriculture frontier of Eastern Brazilian Amazon county of Uruara, the authors show the role of the cattle husbandry in the small holders production systems and the importance of animal health in the sustainability of agriculture frontier through the effects on the cattle productivity. As far as animal health, zoonose diseases, specially brucellosis, are a real critical problem because they are directly related to public well-being. A participative approach with a effective relationship between researchers and farmer organizations has allowed to carry out a zoonose control program and to develop actions towards the increasing of the cattle productivity, as the installation of small factories for processing mineral mixtures and a veterinary vaccination center.