Publications des agents du Cirad

Cirad

Development of a dual recombinant vaccine to protect small ruminants against peste-des-petits-ruminants virus and capripoxvirus infections

Berhe G., Minet C., Le Goff C., Barrett T., Ngangnou A., Grillet C., Libeau G., Fleming M., Black D.N., Diallo A.. 2003. Journal of Virology, 77 (2) : p. 1571-1577.

DOI: 10.1128/JVI.77.2.1571-1577.2003

A recombinant capripoxvirus vaccine containing a cDNA of the peste-des-petits-ruminants virus (PPRV) fusion protein gene was constructed. A quick and efficient method was used to select a highly purified recombinant virus clone. A trial showed that a dose of this recombinant as low as 0.1 PFU protected goats against challenge with a virulent PPRV strain.

Mots-clés : peste des petits ruminants; virologie; capripoxvirus; vaccin synthétique

Article (a-revue à facteur d'impact)

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