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MBT/Pas mouse: A relevant model for the evaluation of Rift Valley fever vaccines

Ayari-Fakhfakh S.E., Zaverucha do Valle T., Guillemot L., Panthier J.J., Bouloy M., Ghram A., Albina E., Cetre-Sossah C.. 2012. Journal of General Virology, 93 (7) : p. 1456-1464.

Currently, there are no worldwide licensed vaccines for Rift Valley fever (RVF) that are both safe and effective. Development and evaluation of vaccines, diagnostics and treatments depend on the availability of appropriate animal models. Animal models are also necessary to understand the basic pathobiology of infection. Here, we report the use of an inbred MBT/Pas mouse model that consistently reproduces RVF disease and serves our purpose for testing the efficacy of vaccine candidates; an attenuated Rift Valley fever virus (RVFV) and a recombinant RVFV-capripoxvirus. We show that this model is relevant for vaccine testing. (Résumé d'auteur)

Mots-clés : testage; efficacité; vaccin; vaccin vivant; modèle; souris; contrôle de maladies; virus de la fièvre de la vallée du rift; tunisie; fièvre de la vallée du rift

Thématique : Maladies des animaux

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