Michael reactions carried out using a bench-top flow system
Bonfils F., Cazaux I., Hodge P., Caze C.. 2006. Organic and Biomolecular Chemistry (3) : p. 493-497.
DOI: 10.1039/B515241K
The Michael reaction between methyl 1-oxoindan-2-carboxylate and methyl vinyl ketone was achieved successfully by pumping solutions of the reactants in toluene through a fluid bed of Amberlyst A21 at 50 °C. The use of a fluid bed reactor is attractive as it allows gel-type beads, i.e. the type of bead used in most studies of polymer-supported (PS) organic reactions, to be used satisfactorily in a flow system. When polymer-supported cinchonidine was used in place of Amberlyst A21, the Michael product was obtained in high yield with an enantiomeric excess (ee) of 51%. This % ee is comparable to that achieved when the reaction was catalysed by cinchonidine itself.
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Agents Cirad, auteurs de cette publication :
- Bonfils Frédéric — Persyst / UPR BioWooEB