The main pathogenic trypanosome found in Asia is Trypanosoma evansi, a parasite originating from Africa, derived from T. brucei, responsible of a disease called surra, which clinical evolution is most often acute and fatal in horses and dogs, and chronic in bovines. Other mammals are receptive but more rarely found infected. Starting in 2008, epidemiological surveys have been carried out in the main hosts in Thailand. Human infections by animal trypanosomes, so called “atypical infections”, are also of concern; a child was found infected by T. lewisi in Thailand in 2008, while a woman was found infected by T. evansi in Vietnam, in 2015. Surveillance on these atypical human infections should be strengthened. Investigations have also been carried out to evaluate the efficacy of a range of trypanocides, both for animals and human treatments. Finally, to circumvent the problem of trypanocides inefficacy, recent investigations are focusing on the control of vectors such as tabanids and stomoxes, using traps and insecticide impregnated screens, to prevent the infection of livestock. A series of workshop was initiated under the cover of the BioZoonoSEA Platform (Biotechnology Platform for Research and Training on Parasitic Zoonoses in SouthEast Asia), to draw links, exchange information and create a small network of researchers involved in biting flies control in SEA. Recent results are exposed, current and future research and perspective are discussed.