Amongst polyphenols, tannins belong to the most effective chemical protection systems against bio-logical attack on trees. Tannins are water-soluble and are thus leached out easily when used for wood protection. In situ polymerized tannin-hexamine wood preservatives have better leaching resistance (LR), but they do not resist weathering. In this study, tannin copolymer formulations were prepared with hexamine, formaldehyde, furfural, glyoxal, furfuryl alcohol and maleic anhydride, impreg-nated in wood, and cured at higher temperatures. The wood samples treated with these formulations were tested for their anti-swelling efficiency (ASE), leaching behavior, mechanical properties, and their resistance against fire, weathering and biological attack. Several tannin-treated specimens showed improved hardness and enhanced leaching and fire resistance. Some formulations also responded well to artificial weathering cycles, but natu-ral weathering cycles deteriorated their performance. Samples treated with maleic anhydride showed improved leachability and high biological resistances, even without the addition of inorganic biocides. These organic and bio-friendly products can be considered as promising alterna-tives to heavy metal-based wood preservatives.