This study investigates the impact of four tapping panel management strategies on cumulative yield growth and laticifer physiology of trees. These strategies were applied to clones PB 260, GT 1, PB 217, and AF 261, belonging to fast, moderate and low metabolic activity, during nine years in south-eastern Côte d'ivoire. The reaction of clones to tapping systems was often dependent on their class of metabolic activity. For all clones, panel management strongly influenced the annual yield. After nine years, however, the cumulative rubber yield did not vary with panel strategy for PB 260, GT 1, and PB 217. Only clone AF 261, a low yielding clone not recommended for planting showed different behaviour. Panel management did not influence the girth increment of trees at nine years for all clones, except for GT 1. For this clone, no panel changing management was more favourable to girth increment than the other strategies. The yield and growth results confirm the known negative relationship between yield and girth increment of the trunk Physiology of the latex cell was influenced by the panel-management strategies for each period of tapping. Latex diagnosis could be used for monitoring year-to-year consecutive tapping on the same panel, to decide whether to change to the other panel if any important physiological stress was detected.