Banana is not only one of the world's favorite fruits but also one of the most important crops for developing countries. The banana reference genome sequence (Musa acuminata) was released recently. Given its taxonomical position, the sequence has particular comparative value highlighted in the recent genome publication providing new insights regarding the evolution of monocotyledons. This study has been enhanced by a number of tools and resources described in this publication. Here, we present all the tools that are available to harness the reference genome sequence and to support post?genomic efforts, such as transcriptomic and metabolomic pathways studies. Several uses cases illustrate how the banana genome hub can be used to study gene families. Overall, with this collaborative effort we discuss the importance of the interoperability towards data integration between existing information systems.