An evaluation of the potential use of the entomopathogen Beauveria bassiana strain 5653 for biologicalcontrol of cabbage major pest, Plutella xylostella was carried out under station and farm conditions in thelittoral ecosystem in Togo. The experiment was conducted using the sprayed solution of B. bassiana 5653 incomparison with synthetic insecticides. The results revealed that the formulation of B bassiana 5653 reducedsignificantly the density of P. xylostella populations. The use of B. bassiana 5653 increased the cabbage yieldby 57% on farm, compared to the control. Contrary to the entomopathogen, the synthetic insecticidesCONQUEST PLUS 388 EC. (16 g acetamipride, 300 g triazophos and 72 g cypermethrin) and DECIS 25 EC. (25 gdeltamethrin) used as references had any effects on P. xylostella densities and cabbage yields compared to thecontrol, indicating that P. xylostella was not susceptible to the synthetic insecticides. Thus, the use of the bioinsecticide B. bassiana 5653 could be an alternative for the management of the insecticide non-susceptiblestrain of P. xylostella in Togo.