Agri-food supply chains are at the heart of sustainable development concerns. In order to comprehend whole complex parameters and their global impacts, it appeared necessary to adopt a systemic approach, justifying a Life Cycle Assessment (LCA), not only from an environmental point of view but from a social and economic one too. Taking into account specificities and stakes of fruits and vegetables (F&V) supply chains in developing countries this paper focus on absences, deficiencies and methodological limits that LCA meets integrating social and economic aspects. The elements presented lead to an in-depth conceptual and theoretical discussion and suggest placing LCA in the perspective of development theory. The proposition is to endow LCA with an approach “by capitals”, which seems particularly adapted to express sustainable development and well-being.