Objective: The Pan American Health Organization (PAHO) regional program introduced to Latin America and the Caribbean (LAC) in 1983 was ratified in 2009 with the goal of eliminating dog-transmitted human rabies by 2015. Despite a >90% decrease in cases, the latter has been extended to 2018 due to persistence in certain areas. In discussions about rabies, LAC are often grouped as one. However, data from Latin America generally obscures the Caribbean situation so that it is inadequately represented in the literature. The present study aims to independently analyse the rabies situation in the Caribbean through use of an internal Caribbean Network (Caribbean Animal Health Network), and to examine the changing epidemiology of the disease in comparison to Latin America. Methods: A questionnaire was developed and administered in February 2014, to the 33 countries or territories of the Caribbean Animal Health Network (CaribVET), through the Adobe Forms Central Web-based platform. Country submissions were collected from April 2014 to June 2015. Responses from30 countries were analysed from June to July 2015 and results were summarized into a regional situation analysis. Complementary information was obtained through a comprehensive literature review using internet searches and the institutional libraries of the PAHO Office in Trinidad and Tobago and the Caribbean Public Health Agency (CARPHA). Selected literature was then summarized and collated with questionnaire responses. Results: Rabies is a notifiable disease in almost all islands and territories of the Caribbean region, where the disease is present in ten countries and/territories (Trinidad and Tobago, Belize, Grenada, Guyana, Suriname, Cuba, Puerto Rico, Dominican Republic, French Guiana and Haiti). In most instances, the disease is endemic in wildlife with periodic spill over into domestic animals; however urban (canine) rabies still occurs in Hispaniola (Dominican Republic and Haiti) and Cuba. Caribbean sylvatic rab