Tomato crop is a agricultural precious commodity worldwide due to high economic returns, nutritive value and role in agricultural and economic diversification. Therefore, tomato demand is booming in sub-Saharan Africa to feed the growing urban populations. But high pest pressure throughout the year, insecticide resistance and the arrival of new species such as tomato leaf miner Tuta absoluta are major constraints in management. Consequently, in sub-Saharan Africa, tomato yield, quality and environmental health practices remain way below international standards. To increase marketable production and quality sustainable pest control is essential. Several alternatives including biopesticide, semiochemical and insect nets are being explored. This study was carried out to evaluate the effectiveness of a high tunnel covered by insect net combined with biopesticides to protect tomato crop against major pests. A statistic block design was implemented in the research centre of KALRO Mwea in Central Kenya during two seasons. Biopesticides based on Bacillus thuringiensis and Metarizium anisopliae were used to complete the physical protection against caterpillars and sucking pests respectively. The results showed that correctly used, insect nets used on high tunnel protect tomatoes against T. absoluta. Whiteflies (Trialeurodes vaporariorum), serpentine leaf miner (Liriomyza spp.) and brown thrips (Frankliniella spp) populations remained at a significantly lower level or arrived later inside the tunnel as compared to open cultivation, but the dark thrips species were much more inside at the flowering stage. Net treatment with permethrin did not provide a significant reduction in pests population as compared to non treated net. Biopesticides recorded significantly low pest populations as compared to the untreated control in open field. The yield was significantly improved mainly due to greenhouse effect. Demonstrations in farmer fields confirmed the effectiveness and affordabilit