Coffee berry disease (CBD), caused by Colletotrichum kahawae, is a major fungal disease of coffee in east Africa, and particularly in Ethiopia. To assess the influence of plot features (elevation and slope) and landscape structure (land use types) on the epidemics of CBD, a study was conducted in 2012 and 2013 in 30 smallholders' coffee plots in southwest Ethiopia. Elevation was the most determining plot feature that influenced the incidence of CBD and berry drops. North-facing coffee plots were affected more by CBD compared to south-facing plots. Landscape structure generally had weak relationship with CBD incidence and berry drops. Overall, coffee growers should give more attention to plot features than landscape structure for CBD management.