Interface areas in Southern Africa that consist of communal lands located at the edge of protected areas face a growing number of human/wildlife coexistence related issues and among them, the risk of pathogen transmission between wild and domesticated species.In this context, the present thesis aims to 1) Characterize the environmental variables, at a landscape scale at three different interfaces located in Southern Africa (hwange National park, Gonarezhou National Park, North Kruger National Park), that potentially influence the movements of two focal species, one wild ungulates species (the buffalo – Syncerus caffer caffer) and one domesticated ungulates species (the cattle – Bos taurus & Bos indicus) 2) Simulate the movements of the focal species, at the individual and herd scales, in relation with their respective environments, 3) Determine the nature, frequency and localization of the contacts between the focal species to better apprehend the risks of pathogen transmission.A temporal series of Sentinel-2 satellite images have been classified to produce monthly surface water and landcover maps at 10 meters spatial resolution. These environmental variables have then been integrated into a spatialized mechanistic movement model based on a collective motion of self-propelled individuals to simulate buffalo and cattle movements and contacts in response to the surface water seasonality and the type of landcover. To spatialized the movements and contacts models, the domain specific language Ocelet has been used. Telemetry data collected in previous studies have been used as reference data to design, calibrate and validate the movement and contact models.Results highlighted strong space and time variabilities of water availability in the three study areas. Landcover classified maps accurately reproduced the specificities in landscape compositions of the three study areas. By only taking surface water into account, the mechanistic movement models showed a positive and s