Natural Deep Eutectic Solvents (NaDES) are liquid mixtures resulting from the association of metabolites such as sugars, organic acids, amino acids, polyols or vitamins. The singularity of NaDES, compared to all the other conventionally encountered solvents, remains in the biological and physiological roles that these mixtures could have in living organisms. Although the presence of NaDES in cells has not yet been demonstrated, we present how these liquid phases could form in-situ and contribute to the cellular functions of living organisms. In the era of green chemistry, NaDES is therefore of particular interest for developing more efficient and sustainable processes in the fields of food industries. Through this talk, we want to show how an approach based on the concept of biomimicry thanks to NaDES could respond to the challenges of transformation (especially using enzymes) and sustainable use of biomass, and open up great eco-innovative opportunities.