Unravelling the origin of SARS-CoV-2: is the model good?
Frutos R., Gavotte L., Devaux C.A.. 2021. New Microbes and New Infections, 43 : 3 p..
MacLean and colleagues recently published a very elegant analysis demonstrating that SARS-CoV-2 carries signs of positive selection and that it was already adapted to humans prior to the emergence of COVID-19. Using the Spillover theory as a reference model for zoonotic emergence, they conclude that SARS-CoV-2 must have acquired this human adaptation in bats. We reinterpreted the data from MacLean et al. using a different model of zoonotic emergence as reference, the Circulation model. The use of the Circulation model provides a more parsimonious interpretation showing that this adaptation to humans occurs in the human population after primo infection.
Mots-clés : coronavirus 2 du syndrome respiratoire aigu sévère; covid-19; chiroptera; zoonose; transmission des maladies; modélisation; genre humain
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Agents Cirad, auteurs de cette publication :
- Frutos Roger — Bios / UMR INTERTRYP