The standard method for pharmaceuticals has numerous obstacles, including the possibility of undesired multidrug resistance, which hinders their availability. In addition, the clinical responses of conventional nanocarriers frequently differ from those anticipated for nano-based treatments. Consequently, new smart drug delivery platforms that respond to inputs and use novel materials have been developed. Several clinical experiments have indicated that these smart drug delivery systems have boosted therapeutic efficiency in several clinical contexts, including infection detection and wound healing. This necessitates designing novel nanocarriers that efficiently carry specific drugs to their target areas. Nonetheless, some disputes are there in terms of their benefits and efficacy. This chapter will carefully discuss the construction and classification of smart nanosystems as drug delivery tools, focusing on wound healing and infection control.