Perennial woody crops, which are crucial to our diets and global economies, have the potential to play a major role in achieving multiple UN Sustainable Development Goals pertaining to biodiversity conservation, socio-economic development and climate change mitigation. However, this potential is hindered by insufficient scientific and policy attention on perennial woody crops, and by the intensification of perennial crop cultivation in the form of monocropping with high external inputs. In this Perspective, we highlight the potential of properly managed and incentivized perennial woody crops to support holistic sustainable development and urge scientists and policymakers to develop an effective agenda to better harness their benefits.