Contagious bovine pleuropneumonia (CBPP) is an infectious disease affecting Bovidae and caused by a mycoplasma: M. mycoides subsp. mycoides. Advances in mycoplasma and molecular biology have opened promising new fields for the development of more effective CBPP vaccines that could be based on various options such as targeted attenuation of live strains, inactivated preparations, adjuvants, subunit vaccines or vectored antigens, modified and targeted delivery systems. The chapter discusses issues related to use of current CBPP vaccines, especially requirements for ensuring the production and use of good-quality CBPP vaccines and strategies for disease control. It considers vaccine specifications and quality assurance; quality control testing of CBPP vaccines; the application of vaccine for CBPP disease control; CBPP vaccination strategy; possible combinations of CBPP vaccine with vaccines of other diseases; and CBPP vaccination monitoring.