In order to ensure food security, it is essential to adapt varieties and crop management systems to the challenges imposed by climate change. Two key components of the breeder's equation are i) the genetic variance potentially mobilizable by breeding programs and ii) the accuracy with which the genetic values of candidates to selection can be predicted. To enable West and Central African sorghum breeding programs to utilize beneficial alleles present in locally non-adapted genetic materials, a large multireference backcross nested association mapping population was developed, based on three regional elite parents and 24 donor parents harboring specific beneficial traits. Each of the 3,901 families was characterized in three to four contrasting environments. A new QTL mapping approach was proposed, allowing the estimation of QTL sensitivity to environmental covariates. This framework allowed the potential effects of detected QTL alleles to be projected into unexplored climatic conditions. A subset of this population, comprising two recurrent and 22 donor parents (2,498 families), was then used to explore the relevance of phenomic selection compared to genomic prediction. Our results showed that phenomic selection can be used in sorghum, but its accuracy depends heavily on the considered traits. We also demonstrated that Near-Infrared Reflectance Spectroscopy (NIRS) data acquired in a reference environment can predict the performance of genotypes characterized in other environments. Furthermore, we suggest that the current methods employed by geneticists to take advantage of spectral information is likely suboptimal, as ten randomly selected wavelengths generally suffice to achieve thte same predictive capabilities as the full spectra. In order to optimize the prediction of genetic values, we demonstrated that Convolutional Neural Networks (CNNs) outperformed traditional genomic prediction models when it came to predicting an integrative trait (fresh aboveground bioma