This thesis analyses the dynamics of infections in a multi-host epidemiological system at the interface between wildlife, livestock and human populations, in the protected areas of Zimbabwe. Increasing human pressures in the Anthropocene Era, such as intensive agriculture, exploitation of natural resources and climate change, are increasing interactions between these three groups. At the wildlife-human interface, this creates a favorable context for the circulation and emergence of pathogens, underlining the need for an integrated approach to understanding these complex dynamics. The interfaces between wildlife, livestock and humans, which are often located in rural areas with poor sanitary facilities, are critical points for examining interspecies transmission mechanisms. The main objective of this research is to study the factors influencing the circulation of the foot-and-mouth disease virus in this context. This pathogen causes a disease with potentially disastrous economic consequences, the epidemiology of which is poorly documented. Through three case studies, the thesis looks at the epidemiological roles within the domestic animal and wildlife compartments. The first study analyses epidemiological data collected on cows and goats in several villages close to protected areas. Thanks to one year's longitudinal serological monitoring, I was able to establish a clear link between distance from protected areas and greater exposure to the virus in cows. This study also highlights individual factors such as species, age and sex that explain the exposure of animals to cattle through farmers' practices. The second study is based on non-invasive ecological (using camera-traps) and epidemiological monitoring of wildlife. This year-long monitoring enabled me to discuss the different epidemiological roles of wild species in the circulation of the foot-and-mouth disease virus by observing contacts between populations at watering points. Finally, the third, exploratory, stu