Introduction: The aim of this study was to estimate the prevalence of digestive tract carriage of ESBL-E/CPE among patients having consulted or been hospitalized in two university hospitals in Lomé in 2023. Methods: A cross-sectional study was conducted from January to June 2023. Rectal swabs were collected from 230 participants (100 in maternity, 50 in pediatrics, 50 in trauma-orthopedics, and 30 in intensive care). Results: Median age was four years for children and 30 years for adults. Overall prevalence of ESBL-E carriage was 59.6 %, while that of CPB was 6.1 %. Carriage was more frequent in hospital settings than in the community (64.6 % vs. 53.0 %). The main isolated species were Escherichia coli (95.6 %) and Klebsiella pneumoniae (27.7 %). Hospitalization units were associated with multidrug-resistant bacteria carriage. Conclusion: These findings highlight a high prevalence of digestive tract carriage in hospital as well as community settings.