Background: Despite the significant impact of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) on malaria, 597,000 deaths from malaria were still recorded in 2023. Additional measures are clearly needed to complement current tools. We assessed the efficacy of insecticide-treated window screens (a piece of PermaNet 3.0 containing deltamethrin¿+¿piperonyl butoxide) versus untreated window screening and eave tube inserts treated with ß-cyfluthrin as household interventions against Anopheles gambiae sensu lato. Method: Between August and October 2022, five experimental houses in Kolongonouan village, central Côte d'Ivoire, were used under semi-field conditions to evaluate the following interventions: (i) standard control house with small openings in the eaves and no window screens (SCH); (ii) insecticide-treated screening (ITS) of windows with small openings in the eaves (ITS op); (iii) ITS of windows with eaves blocked to prevent mosquito entry via eaves (ITS blq); (iv) insecticide treatment applied to the eaves using In2Care eave tubes, without window screening (ET); and (v) untreated window screening together with insecticide-treated eave tubes (SET). The efficacy of these treatments on the indoor and outdoor density of naturally recruiting Anopheles gambiae mosquitoes was assessed by human landing catches from 6:00 pm to 8:00 am. The impact of these treatments on mosquito mortality and blood-feeding rates was further assessed using release–recapture experiments, in which large enclosures were built around individual houses and approximately 100 non-blood-fed female An. gambiae were released each night over 15 nights. In addition, for the ITS blq treatment, the importance of physical integrity was assessed by evaluating the effect of damaging the screening with two or four 4 cm¿×¿4 cm holes in each screened window. Results: Insecticide-treated window screening plus eave blocking (ITS blq) significantly reduced by 31.8% the number of An. gambi