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Salmonella enterica serotype typhi with nonclassical quinolone resistance phenotype

Accou-Demartin M., Gaborieau V., Song Y., Roumagnac P., Marchou B., Achtman M., Weill F.X.. 2011. Emerging Infectious Diseases, 17 (6) : p. 1091-1094.

We report Salmonella enterica serotype Typhi strains with a nonclassical quinolone resistance phenotype (i.e., decreased susceptibility to ciprofloxacin but with susceptibility to nalidixic acid) associated with a nonsynonymous mutation at codon 464 of the gyrB gene. These strains, not detected by the nalidixic acid disk screening test, can result in fluoroquinolone treatment failure. (Résumé d'auteur)

Thématique : Maladies des animaux

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