Phenolic compounds represent a huge amount of potential bioactive candidates. Concomitantly, there is a need of conceiving effective delivery systems that would deliver such molecules to the specific locations where they would express their optimal activities. Deep Eutectic Solvents (DES) have emerged recently. These are composed of two or more components that are able to self-associate by non-covalent interactions to form a mixture with a phase transition temperature (solid-liquid) significantly lower than that of each individual component. Recently, the term Natural Deep Eutectic Solvents (NaDES) was used to describe such a DES obtained by combining molecules abundantly present in the cellular constituents. It is postulated that NaDES may be an alternative medium to water and lipids in living organisms, and although their accurate role and discovery in cells is still in investigation, their presence could explain numerous biological processes such as the biosynthesis or storage of various non-water soluble metabolites and macromolecules. The molecules forming a NaDES are connected to one another through a well-organized tridimensional system with optimum interactions via inter- and intra- molecular hydrogen-bonding. From that state of the art, we have set the hypothesis that NaDES paired with bioactive molecules could result in an efficient new delivery system. Herein, we present some examples on the activity of such formulated antioxidants in cell systems and heterophasic media.