The antioxidant interactions of a- and ¿-tocopherol with curcumin and quercetin were assessed in an oil-in-water emulsion using the WIM-CAT assay, a method integrating Weibull interaction modeling with the conjugated autoxidizable triene technique. Synergistic effects were strongest for ¿-tocopherol with curcumin and for a-tocopherol with quercetin, particularly at low tocopherol concentrations (0.2¿µM in emulsion, 380¿ppm in oil) and high molar ratios (3:1). Increasing tocopherol concentration to 0.6¿µM in emulsion (1140¿ppm in oil) reduced synergy, likely reflecting pro-oxidant activity. The presence of ferrous ions accelerated oxidation but did not influence synergistic interactions, while acidic conditions reduced tocopherol pro-oxidation and modified the effects of curcumin and quercetin. Weibull modeling revealed isoform-dependent differences during the propagation phase of oxidation. Cyclic voltammetry further suggested that the synergy of a-tocopherol may involve antioxidant regeneration mechanisms, whereas ¿-tocopherol appears to act through alternative redox processes. Together, kinetic and electrochemical analyses provide complementary insights into the conditions governing antioxidant interactions.