High-pressure homogenization (HPH) was applied within a range of 300 to 1000¿bar for 2 to 8 cycles. At constant dry matter (6.2%), pulp mass increased from 3.7 to 8%, indicating a change in particle organization. D90 varied from 197 to 20¿µm depending on the pressure and number of cycles. The aggregation of particles, then destruction of the aggregates depending on the number of cycles, explained viscosity behavior. HPH delayed phase separation by an average 28.5 h. Sedimentation velocity was 10 times higher at 8 cycles than at 3 cycles, at 1000¿bar. At 1000¿bar, browning was observed, resulting from Maillard reactions, and was linked to the furan-2-pentyl content (10-fold higher) and a 45% loss of carotenoids. This study will help in understanding changes induced in mango nectar by HPH and will be of use in developing processing technologies to preserve mango-based products.